PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factorNF-κBinhibitor and derives from the p65 subunit ofNF-κBamino acid residues 271-282, which selectively inhibitsNF-κBactivation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulateapoptosis^[1][2].

NF-kappaB^[1]

PTD-p65-P1 Peptide TFA (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM^[1].
PTD-p65-P1 Peptide TFA (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation^[1].
PTD-p65-P1 Peptide TFA (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%^[1].
PTD-p65-P1 Peptide TFA (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF^[1].
PTD-p65-P1 Peptide TFA (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation^[2].

3943.52

Solid

C₁₇₀H₂₇₆F₃N₅₇O₄₆S

DRQIKIWFQNRRMKWKKQLRRPSDRELSE

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)