Anti-inflammatory agent 21

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CAS NO:

2408836-40-6

Anti-inflammatory agent 21 (compound 9o) 是一种具有口服活性且低细胞毒性的抗炎剂，对 NO 的IC₅₀为 0.76 μM。Anti-inflammatory agent 21 通过积累ROS、阻断NF-κB/MAPK信号通路来发挥抗炎作用。 Anti-inflammatory agent 21 对关节炎大鼠模型的软骨破坏和炎症细胞浸润有一定的改善作用。

生物活性	Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with anIC₅₀value of 0.76 μM forNO. Anti-inflammatory agent 21 acts via accumulationROSand blocks theNF-κB/MAPKsignaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model^[1].
IC₅₀& Target	IC₅₀: 0.76 μM (NO)^[1]
分子量	424.42
Formula	C₂₄H₂₁FO₆
CAS 号	2408836-40-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.