(E)-Guanabenz

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(E)-Guanabenz

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60329-03-5

(E)-Wy-8678

(E)-Guanabenz ((E)-Wy-8678) 是一种具有口服活性的中枢α2-肾上腺素受体 (α2-adrenoceptor)激动剂。(E)-Guanabenz 具有降血压活性，通过刺激中枢 α2- 肾上腺素受体，并减少交感神经向外周的净流出来降低血压。(E)-Guanabenz 也直接结合并抑制 GADD34，具有神经保护活性。(E)-Guanabenz 可用于高血压和帕金森病的研究。

生物活性

(E)-Guanabenz ((E)-Wy-8678) is an orally active centralα2-adrenoceptoragonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease^[1]^[2].

IC₅₀& Target

α2-adrenoceptor, GADD34^[1]^[2]

Clinical Trial

分子量

231.08

Formula

C₈H₈Cl₂N₄

CAS 号

60329-03-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.