Dehydrocurdione

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Dehydrocurdione

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CAS NO:

38230-32-9

Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶(HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。

生物活性

Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase(HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts withKeap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity^[1]^[2].

体外研究
(In Vitro)

Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM^[1].
Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer^[1].

Western Blot Analysis^[1]

Cell Line:	RAW 264.7 cells
Concentration:	100 μM
Incubation Time:	24 hours
Result:	Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr.

体内研究
(In Vivo)

Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis^[2].
Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema^[2].

Animal Model:	Wistar rats^[2]
Dosage:	120 mg/kg
Administration:	P.o ; daily for 12 days
Result:	Significantly reduces chronic adjuvant arthritis.

分子量

234.33

Formula

C₁₅H₂₂O₂

CAS 号

38230-32-9

结构分类

Terpenoids
Sesquiterpenes

来源

Plants
Zingiberaceae
Curcuma zedoaria

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.