CAP18(rabbit)

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CAP18(rabbit)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

152742-15-9

CAP18 (rabbit) 是一种 37 个氨基酸的抗菌肽，最初从兔粒细胞中分离出来。CAP18 (rabbit) 对革兰氏阳性 (IC₅₀，130-200 nM) 和革兰氏阴性 (IC₅₀，20-100 nM) 细菌均具有广泛的抗菌活性，并可用于细菌败血症的研究。

生物活性

CAP18 (rabbit) is a 37amino acidsantimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against bothGram-positive(IC₅₀, 130-200 nM) andGram-negative(IC₅₀, 20-100 nM)bacteria. CAP18 (rabbit) has the potential forbacterialsepsis research^[1].

IC₅₀& Target

IC50: 130-200 nM (Gram-positive bacteria); 20-100 nM (Gram-negative bacteria)

分子量

4433.47

Formula

C₂₀₂H₃₅₆N₆₄O₄₇

CAS 号

152742-15-9

Sequence Shortening

GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKLAPRTDY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.