Quinine hemisulfate hydrate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

207671-44-1

硫酸奎宁水合物

Quinine hemisulfate hydrate 是一种从金鸡纳树皮中提取的生物碱，具有抗疟疾的作用。Quinine hemisulfate hydrate 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (K_Ca5.1) 通道 +100 mV 电流, 其IC₅₀值为 169 μM。

生物活性

Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is apotassium channelinhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV, with anIC₅₀of 169 μM^[1]^[2].

IC₅₀& Target

IC50: Parasite^[1], 169 μM (mSlo3)^[2]

Clinical Trial

分子量

391.48

Formula

C₂₀H₂₄N₂O₂.1/2H₂O₄S.H₂O

CAS 号

207671-44-1

中文名称

硫酸奎宁水合物

结构分类

Alkaloids
Quinoline Alkaloids

来源

Plants
Rubiaceae
Cinchona ledgeriana(Howard) Moens et Trim

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.