T-0156

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T-0156

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

324572-93-2

T-0156 是一种有效的选择性 5 型磷酸二酯酶 (PDE5) 抑制剂。T-0156 以竞争方式特异性抑制 PDE5 对环磷酸鸟苷 (cGMP) 的水解 (IC₅₀=0.23 nM)。T-0156 对 PDE6 具有弱抑制作用 (IC₅₀=56 nM)，对 PDE1、PDE2、PDE3 和 PDE4 具有低效力 (IC₅₀>10 μM)。T-0156 增强一氧化氮 (NO)/cGMP 途径。

生物活性

T-0156 is a potent and selectivephosphodiesterasetype 5 (PDE5)inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) byPDE5in a competitive manner (IC₅₀=0.23 nM). T-0156 inhibitsPDE6(IC₅₀=56 nM) and has low potencies againstPDE1,PDE2,PDE3, andPDE4(IC₅₀>10 μM). T-0156 enhances the nitric oxide (NO)/cGMP pathway^[1].

IC₅₀& Target^[1]

PDE5

0.23 nM (IC₅₀)

PDE1

>100 μM (IC₅₀)

PDE2

>100 μM (IC₅₀)

PDE3

>100 μM (IC₅₀)

PDE4

63 μM (IC₅₀)

PDE6

56 nM (IC₅₀)

体外研究
(In Vitro)

T-0156 at 10 and 100 nM increases cGMP levels, causing relaxation of the tissue in the isolated rabbit corpus cavernosum^[1].

分子量

620.05

Formula

C₃₁H₃₀ClN₅O₇

CAS 号

324572-93-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.