(S)-C33

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(S)-C33

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2066488-39-7

(S)-C33 是一种有效的选择性PDE9(磷酸二酯酶 -9) 抑制剂，其IC₅₀为 11 nM。(S)-C33 可用于中枢神经系统疾病和糖尿病的研究。

生物活性

(S)-C33 is a potent and selectivePDE9(phosphodiesterase-9)inhibitor, with anIC₅₀of 11 nM. (S)-C33 can be used for central nervous system diseases and diabetes research^[1].

IC₅₀& Target

PDE9A

11 ± 4 nM (IC₅₀)

PDE5A1

366 ± 38 nM (IC₅₀)

PDE1B

554 ± 64 nM (IC₅₀)

PDE4D2

1.3 ± 0.1 μM (IC₅₀)

PDE10A1

2.3 ± 0.3 μM (IC₅₀)

PDE2A

2.4 ± 0.5 μM (IC₅₀)

分子量

357.84

Formula

C₁₈H₂₀ClN₅O

CAS 号

2066488-39-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 100 mg/mL(279.45 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7945 mL	13.9727 mL	27.9454 mL
5 mM	0.5589 mL	2.7945 mL	5.5891 mL
10 mM	0.2795 mL	1.3973 mL	2.7945 mL