Olprinone

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Olprinone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	106730-54-5
包装:	10mg
市场价:	1060元

奥普力农
Loprinone

Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC₅₀分别为 150、100、0.35 和 14 μM。Olprinone 因其正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone 具有抗炎活性。

生物活性

Olprinone (Loprinone) is a potentphosphodiesterase (PDE)3inhibitor, withIC₅₀s of 150, 100, 0.35 and 14 μM forPDE1,PDE2,PDE3andPDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity^[1]^[2].

IC₅₀& Target^[1]

PDE1

150 μM (IC₅₀)

PDE2

100 μM (IC₅₀)

PDE3

0.35 μM (IC₅₀)

PDE4

14 μM (IC₅₀)

体内研究
(In Vivo)

Olprinone (Loprinone) (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats^[1].

Animal Model:	Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)^[1]
Dosage:	0.2 mg/kg
Administration:	I.p. (administered 15 min after ischemia)
Result:	Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).

分子量

250.26

Formula

C₁₄H₁₀N₄O

CAS 号

106730-54-5

中文名称

奥普力农

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.