PF-03049423

立即咨询

PF-03049423

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

402955-58-2

PF-03049423 (Compound PF-5) 是一种有效的，高选择性的phosphodiesterase-5A抑制剂，对大鼠和人血小板酶的IC₅₀约为 0.2 nM。PF-03049423 可用于急性缺血性中风的研究。

生物活性

PF-03049423 (Compound PF-5) is a potent and highly selectivephosphodiesterase-5Ainhibitor with anIC₅₀of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke^[1].

IC₅₀& Target^[1]

PDE5A

rat and human platelet enzyme

~0.2 nM (IC₅₀)

体内研究
(In Vivo)

PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion^[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion^[1].

Animal Model:	Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model^[1]
Dosage:	0.1, 1, or 10 mg/kg
Administration:	Subcutaneous injection, b.i.d. for 7 days
Result:	Improved functional recovery at 1 mg/kg and 10 mg/kg.

Clinical Trial

Formula

C₂₄H₃₂N₆O₄.xHCl

CAS 号

402955-58-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.