CJJ300

立即咨询

CJJ300

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1807631-83-9

CJJ300 是一个转化生长因子-β (TGF-β) 抑制剂，IC₅₀值为 5.3 μM。CJJ300 通过阻断 TGF-β-TβR-I-TβR-II signaling complex 的形成来抑制 TGF-β signaling。

生物活性

CJJ300 is atransforming growth factor-β(TGF-β) inhibitor with anIC₅₀of 5.3 μM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex^[1].

IC₅₀& Target

IC₅₀: 5.3 μM (TGF-β1-induced luciferase)^[1]

体外研究
(In Vitro)

CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC₅₀= 23.6 ± 5.8 μM)^[1].
CJJ300 (0-80 μM, 2 h) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, and suppresses the expression of markers of EMT (epithelial-mesenchymal transition) without cytotoxicity^[1].
CJJ300 suppresses TGF-β induced cell migration^[1].

Western Blot Analysis^[1]

Cell Line:	Human A549 lung epithelial cells
Concentration:	20, 40, and 80 μM
Incubation Time:	2 h
Result:	Significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2 and P-Akt induced by TGF-β. Down regulated the expression of EMT-associated proteins, including fibronectin, α-SMA and MMP-2 in a dose-dependent manner.

分子量

435.60

Formula

C₃₀H₃₃N₃

CAS 号

1807631-83-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.