TP0427736 hydrochloride

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CAS NO:

2459963-17-6

TP0427736 hydrochloride 是一种有效的ALK5激酶活性抑制剂，IC₅₀为 2.72 nM，这种作用比对 ALK3 的抑制作用高 300 倍 (抑制 ALK3 的 IC₅₀为 836 nM)。TP0427736 hydrochloride 还抑制由 TGF-β1 诱导的 A549 细胞中的 Smad2/3 磷酸化，IC₅₀值为 8.68 nM。TP0427736 hydrochlor

生物活性	TP0427736 hydrochloride is a potent inhibitor ofALK5kinase activity with anIC₅₀of 2.72 nM and this effect is 300-fold higher than the inhibitory effect onALK3(IC₅₀=836 nM). TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced byTGF-β1with an IC₅₀value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA)^[1].
分子量	334.85
Formula	C₁₄H₁₁ClN₄S₂
CAS 号	2459963-17-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.