SNIPER(ABL)-039，由 Dasatinib (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (IAP配体) 组合而成，可有效降解BCR-ABL蛋白，DC50为 10 nM。对ABL，cIAP1，cIAP2，XIAP 的IC50分别为 0.54 nM，10 nM，12 nM 和 50 nM。
| 生物活性 | SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAPligand) with a linker, induces the reduction ofBCR-ABLprotein with a DC50of 10 nM.IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM forABL,cIAP1, cIAP2,XIAP, respectively[1]. |
| IC50& Target[1] | Abl 0.54 nM (IC50) | cIAP1 10 nM (IC50) | cIAP2 12 nM (IC50) | XIAP 50 nM (IC50) | SNIPER | Abl 10 nM (DC50) |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
