(S)-CR8 是 CR8 的 S 型异构体。(S)-CR8 是一种有效的选择性CDK抑制剂，对 CDK2/cyclin E、CDK2/cyclin A、CDK9/cyclin T、CDK5/p25 和 CDK1/cyclin B 的IC50分别为 0.060、0.080、0.11、0.12 和 0.15 μM。(S)-CR8 降低 SH-SY5Y 细胞存活率，IC50为0.40 μM。
| 生物活性 | (S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selectiveCDKinhibitor withIC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC500.40 μM)[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
