Cyclo(Arg-Gly-Asp-D-Phe-Val)TFA

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CAS NO:

199807-33-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 是一种整合素αvβ3抑制剂。Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 具有抗肿瘤活性。Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 可用于急性髓系白血病的研究。

生物活性

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is anintegrinαvβ3inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia^[1].

IC₅₀& Target

αvβ3^[1]

体外研究
(In Vitro)

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents^[1].

Cell Cycle Analysis^[1]

Cell Line:	MV4-11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis^[1]

Cell Line:	MV4-11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Increased the apoptosis rates.

分子量

688.65

性状

Solid

Formula

C₂₈H₃₉F₃N₈O₉

CAS 号

199807-33-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)