6-Dehydrogingerdione

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CAS NO:

76060-35-0

6-Dehydrogingerdione 通过活性氧介导 DR5 的增加，使人肝母细胞瘤 Heg2 细胞对 TRAIL 诱导的凋亡敏感。

生物活性

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-inducedapoptosisvia reactive oxygen species-mediated increase of DR5^[1].

体外研究
(In Vitro)

6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways^[1].
6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation^[1].
6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway^[1].

Apoptosis Analysis^[1]

Cell Line:	Hep G2 cells.
Concentration:	0, 50, 100 μM.
Incubation Time:	24 h.
Result:	Induced Apoptosis in Hep G2 Cells.

分子量

290.35

Formula

C₁₇H₂₂O₄

CAS 号

76060-35-0

结构分类

Phenols
Monophenols

来源

Plants
Zingiberaceae
Zingiber officinale

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.