CBP/p300-IN-20

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CBP/p300-IN-20

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CBP/p300-IN-20 是一种有效和选择性的p300/CBP抑制剂，对 p300 的pIC₅₀为 10.1。CBP/p300-IN-20 可用于癌症相关研究。

生物活性

CBP/p300-IN-20 is a potent and selectivep300/CBPinhibitor, with apIC₅₀of 10.1 for p300. CBP/p300-IN-20 can be used for the research ofcancer^[1].

IC₅₀& Target^[1]

CBP/p300

10.1 (pIC₅₀)

体外研究
(In Vitro)

CBP/p300-IN-20 (compound 28) decreases Myc protein in cell-based cMyc HTRF assay, with a pEC₅₀of 8.5^[1].
CBP/p300-IN-20 (1 μM) shows 97% inhibition for p300 and 80% inhibition for CPB^[1].
CBP/p300-IN-20 (0.3-1000 nM; 2 h) decreases H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3 in COLO 320HSR cells^[1].

Western Blot Analysis^[1]

Cell Line:	COLO 320HSR cells
Concentration:	0.3, 1, 3, 10, 30, 100, 300, 1000 nM
Incubation Time:	2 hours
Result:	Caused a rapid concentration-dependent decrease in H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3.

体内研究
(In Vivo)

CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits C_max(210 ng/mL), AUC_0→∞(102 hong/mL), CL (95 mL/min/kg), and T_1/2(0.3 h) in rats^[1].

分子量

477.87

Formula

C₂₂H₁₉ClF₃N₅O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.