CBP/p300-IN-19 hydrochloride

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CAS NO:

2592638-14-5

CBP/p300-IN-19 hydrochloride 是一种有效的选择性p300/CBP HAT抑制剂，p300-HAT, CBP-HAT, PCAF, Myst3 的IC₅₀s 分别为 1.4, 2.2, >100, >100 μM。CBP/p300-IN-19 hydrochloride 显示出抗肿瘤活性

生物活性

CBP/p300-IN-19 hydrochloride is a potent and selectivep300/CBP HATinhibitor withIC₅₀s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity^[1].

IC₅₀& Target^[1]

Myst3

>100 μM (IC₅₀)

p300-HAT

1.4 μM (IC₅₀)

CBP-HAT

2.2 μM (IC₅₀)

PCAF

>100 μM (IC₅₀)

体外研究
(In Vitro)

CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC₅₀s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 μM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively^[1].
CBP/p300-IN-19 hydrochloride (0, 5, 10 μM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27^[1].

Western Blot Analysis^[1]

Cell Line:	Kasumi-1 leukemia cells
Concentration:	0, 5, 10 μM
Incubation Time:	12 h
Result:	Dose-dependently inhibited the acetylation of H3K18, H3K9 and K27.

分子量

514.01

Formula

C₃₀H₂₈ClN₃O₃

CAS 号

2592638-14-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.