AChE-IN-21

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AChE-IN-21

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2413656-04-7

AChE-IN-21 (Compound I-8) 是一种有效的、选择性的、具有口服活性的AChE抑制剂，IC₅₀值为 2.66 nM。AChE-IN-21 在体外具有良好的血脑屏障通透性。

生物活性

AChE-IN-21 (Compound I-8) is a potent, selective and orally activeAChEinhibitor with anIC₅₀of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro^[1].

IC₅₀& Target

EeAChE

2.66 nM (IC₅₀)

RatBuChE

19.10 μM (IC₅₀)

体外研究
(In Vitro)

AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE^[1].

体内研究
(In Vivo)

AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice^[1].

Animal Model:	Kunming mice at body weight of 18–22 g (male and female in half)^[1]
Dosage:	1.0, 5.0 and 25.0 mg/kg
Administration:	Intragastric administration, once a day for 7 consecutive days
Result:	Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.

分子量

395.49

Formula

C₂₄H₂₉NO₄

CAS 号

2413656-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.