SIRT2-IN-10

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SIRT2-IN-10

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

296793-09-4

SIRT2-IN-10 (Compound 12) 是一种有效的SIRT2抑制剂，IC₅₀为 1.3 μM。SIRT2-IN-10 可用于癌症和神经退行性疾病的研究。

生物活性

SIRT2-IN-10 (Compound 12) is a potentSIRT2inhibitor with anIC₅₀of 1.3 μM. SIRT2-IN-10 can be used for the research ofcancerand neurodegenerative disease^[1].

IC₅₀& Target

SIRT2^[1]

体外研究
(In Vitro)

SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner^[1].
SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM
Incubation Time:	72 h
Result:	Inhibited the proliferation in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cells
Concentration:	6.25, 12.5, 25 and 50 μM
Incubation Time:	6 h
Result:	Dose-dependently increased the acetylation level of α-tubulin.

分子量

475.56

Formula

C₂₈H₂₁N₅OS

CAS 号

296793-09-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.