SRT3657

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SRT3657

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1383551-17-4

SRT3657 是一种可透过血脑屏障的SIRT1激活剂，具有神经保护作用。

生物活性

SRT3657 is a brain-permeable activator ofSIRT1, with neuroprotective effect^[1].

IC₅₀& Target

SIRT1^[1]

体内研究
(In Vivo)

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice^[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments^[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)^[1].

Animal Model:	Adult double-transgenic CK-p25 mice (3-month-old)^[1]
Dosage:	30 mg/kg
Administration:	Oral gavage, daily, for 6 weeks
Result:	Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.

分子量

774.97

Formula

C₄₀H₅₄N₈O₆S

CAS 号

1383551-17-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.