Buspirone

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Buspirone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

36505-84-7

丁螺环酮

Buspirone 是一种口服有效的 5-HT1A 受体激动剂 (5-HT1A receptor)。Buspirone 是一种有效的抗癌剂。Buspirone 显示出抗增殖活性。Buspirone 可用于焦虑和抑郁研究。

生物活性

Buspirone is an orally active5-HT1A receptoragonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression andcancerresearch^[1]^[2].

体外研究
(In Vitro)

Buspirone (0-400 μg/mL; 6 hours) has cytotoxic effect in Lymphocytes^[1]. Buspirone (0-180 μg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)^[1].

Cell Viability Assay^[1]

Cell Line:	Lymphocytes
Concentration:	0, 4, 20, 40, 200 and 400 μg/mL
Incubation Time:	6 hours
Result:	Decreased cell viability in a dose-dependent manner.

体内研究
(In Vivo)

Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors^[2].
Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota^[2].

Animal Model:	Male C57BL/6N mice^[2]
Dosage:	1 and 5 mg/kg
Administration:	Oral gavage and intraperitoneal injection; for 5 days
Result:	Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon.

Animal Model:	Male C57BL/6N mice^[2]
Dosage:	1 and 5 mg/kg
Administration:	Oral gavage and intraperitoneal injection; for 5 days
Result:	Reduced the IS- or EC-induced gut Proteobacteria population.

Clinical Trial

分子量

385.50

Formula

C₂₁H₃₁N₅O₂

CAS 号

36505-84-7

中文名称

丁螺环酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.