3-Deoxysappanchalcone

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CAS NO:

112408-67-0

3-Deoxysappanchalcone 是一种从豆科植物Caesalpinia sappan L.中分离得到的天然查尔酮化合物，具有抗过敏、抗病毒、抗炎和抗氧化活性。3-Deoxysappanchalcone 通过激活小鼠巨噬细胞中 AKT/mTOR 通路诱导血红素加氧酶 -1 (HO-1) 的表达，发挥抗炎作用。3-Deoxysappanchalcone 具有抗流感病毒活性 (H3N2,IC₅₀= 1.06 μM)。

生物活性

3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated fromCaesalpinia sappan L.(Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2,IC₅₀= 1.06 μM)^[1]^[2].

IC₅₀& Target

IC50: 1.06 μM (H3N2)^[2]

分子量

270.28

性状

Solid

Formula

C₁₆H₁₄O₄

CAS 号

112408-67-0

结构分类

Flavonoids
Chalcones

Phenols
Polyphenols

来源

Plants
Leguminosae
Caesalpinia sappanL.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(184.99 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.6999 mL	18.4993 mL	36.9987 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。