Pronethalol hydrochloride

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CAS NO:

51-02-5

(±)-Pronethalo hydrochloride

Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的Sox2表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常，也可以限制脑动静脉畸形 (AVMs)。

生物活性	Pronethalol ((±)-Pronethalo) is a non-selectiveβ-adrenergicantagonist. Pronethalol is a potent inhibitor ofSox2expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)^[1]^[2].
体外研究 (In Vitro)	Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment^[2].
体内研究 (In Vivo)	Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) inMgp^–/–mice^[2].
分子量	265.78
Formula	C₁₅H₂₀ClNO
CAS 号	51-02-5
中文名称	盐酸普罗纳赛洛；盐酸丙萘洛尔
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.