Phentolamine

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Phentolamine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

50-60-2

酚妥拉明

Phentolamine 是一种有效的、选择性的和具有口服活性的α1 肾上腺素和α2 肾上腺素受体拮抗剂。Phentolamine 可用于治疗勃起功能障碍。

生物活性

Phentolamine is a potent, selective and orally activeα1 adrenergicandα2 adrenergicreceptor antagonist. Phentolamine can be used for the treatment of erectile dysfunction^[1]^[2]^[3].

体内研究
(In Vivo)

Phentolamine (5-20 mg/kg; i.p.) effectively inhibits the seizures elicited by strychnine (2 mg/kg, i.p.) and attenuates the seizure-potentiating effect of DOPS (4 mg/kg, i.p.) in mouse^[2].
Phentolamine (1 mg/kg; i.p.) increases insulin secretion by inhibition of b-cell a2A-adrenoceptors in mouse^[3].

Animal Model:	WT mice^[3]
Dosage:	1 mg/kg
Administration:	IP
Result:	Reduced blood glucose and increased insulin levels.

Clinical Trial

分子量

281.35

Formula

C₁₇H₁₉N₃O

CAS 号

50-60-2

中文名称

酚妥拉明

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.