Aprocitentan D4 (ACT-132577 D4) 是 Aprocitentan 氘代物。Aprocitentan 是 Macitentan 的主要且具有药理活性的代谢产物。Aprocitentan 是双重ETA/ETB拮抗剂，IC50分别为 3.4 nM 和 987 nM，pA2值分别为 6.7 和 5.5。
| 生物活性 | Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dualETA/ETBantagonist withIC50s of 3.4 nM and 987 nM, andpA2valus of 6.7 and 5.5, respectively[1]. |
| IC50& Target[1] | ETA 3.4 nM (IC50) | ETA 6.7 (pA2) | ETB 987 nM (IC50) | ETB 5.5 (pA2) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
