BCX 1470 能抑制factor D和C1s的酯水解活性，IC50分别为 96 nM 和 1.6 nM。
| 生物活性 | BCX 1470 inhibits the esterolytic activity offactor D(IC50=96 nM) andC1s(IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
| IC50& Target | IC50: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) |
体外研究
(In Vitro) | BCX 1470 is serine protease inhibitor. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
