Rofecoxib-d5

立即咨询

Rofecoxib-d5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

544684-93-7

罗非考昔 d5

Rofecoxib (D5) (MK 966 (D5)) 是 Rofecoxib 的氘代物。Rofecoxib 是一种有效的，可口服的COX-2特异性抑制剂，在人骨肉瘤细胞和中国仓鼠卵巢细胞中，对人 COX-2 的IC₅₀值分别为 26 和 18 nM；Rofecoxib 对 COX-2 的选择性是对人 COX-1 的 1000 倍，在 U937 细胞和中国仓鼠卵巢细胞中，IC₅₀值分别为 >50 μM 和 >15 μM。

生物活性	Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally activeCOX-2inhibitor, withIC₅₀s of 26 and 18 nM for humanCOX-2in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity forCOX-2over humanCOX-1(IC₅₀>50 μM in U937 cells and >15 μM in Chinese hamster ovary cells)^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
分子量	319.39
Formula	C₁₇H₉D₅O₄S
CAS 号	544684-93-7
中文名称	罗非考昔 d5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.