(E)-[6]-Dehydroparadol

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CAS NO:

878006-06-5

(E)-[6]-Dehydroparadol 是 [6]-Shogaol (HY-14616) 的氧化代谢产物，是一种有效的Nrf2活化剂。(E)-[6]-Dehydroparadol 可抑制人癌细胞的生长并诱导其凋亡。

生物活性

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potentNrf2activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce theapoptosisof humancancercells^[1]^[2].

IC₅₀& Target

Nrf2^[2]

体外研究
(In Vitro)

(E)-[6]-Dehydroparadol (M15) (5-80 μM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC₅₀s of 43.02 and 41.59 μM, respectively^[1].
(E)-[6]-Dehydroparadol (10-40 μM; 24 h) induces apoptosis in HCT-116 and H-1299 cells^[1].

体内研究
(In Vivo)

(E)-[6]-Dehydroparadol (compound 19) (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos^[2].

分子量

276.37

性状

Solid

Formula

C₁₇H₂₄O₃

CAS 号

878006-06-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 140 mg/mL(506.57 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.6183 mL	18.0917 mL	36.1834 mL
5 mM	0.7237 mL	3.6183 mL	7.2367 mL
10 mM	0.3618 mL	1.8092 mL	3.6183 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。