Beclometasone dipropionate monohydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

77011-63-3

Beclometasone dipropionate monohydrate 是 Beclometasone 的前体药物，是口服有效的糖皮质激素受体激动剂。Beclometasone dipropionate monohydrate 通过糖皮质激素受体发挥作用，抑制炎症和过度增殖。Beclometasone dipropionate monohydrate 可用于哮喘研究。

生物活性

Beclometasone dipropionate monohydrate, the prodrug of Beclometasone, is an orally active and potentglucocorticoid recepteragonist. Beclometasone dipropionate monohydrate acts via aglucocorticoid receptorand suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma^[1]^[2].

体外研究
(In Vitro)

Beclometasone dipropionate monohydrate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells^[2].

Western Blot Analysis^[2]

Cell Line:	16HBE cells
Concentration:	1, 10 and 100 nM
Incubation Time:	20 min
Result:	Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.

体内研究
(In Vivo)

Beclometasone dipropionate monohydrate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number^[1].

Animal Model:	Male BALB/c mice with asthma^[1]
Dosage:	150 μg/kg
Administration:	Nebulization
Result:	Decreased total cell number and relative eosinophil number in BALF.

Clinical Trial

分子量

539.06

Formula

C₂₈H₃₉ClO₈

CAS 号

77011-63-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.