Benztropine

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Benztropine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

86-13-5

Benzatropine
Benzotropine

Benztropine (Benzatropine; Benzotropine) 是一种具有口服活性的中枢性抗胆碱能剂，可用于帕金森氏病的研究。Benztropine 是一种抗组胺剂和多巴胺再摄取 (dopamine reuptake) 抑制剂。Benztropine 也是一种人 D₂多巴胺受体 (human D₂dopamine receptor) 的变构拮抗剂，并且具有抗癌作用。

生物活性

Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research^[1]. Benztropine is an anti-histamine agent and adopamine re-uptakeinhibitor. Benztropine is also ahuman D₂dopamine receptorallosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects^[2].

体外研究
(In Vitro)

Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC₅₀value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne^[1].
Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors^[1].
Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination^[1].

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231
Concentration:	0, 0.1, 0.625, 1.25, 2.5, 5, 10 μM
Incubation Time:	72 hours
Result:	Inhibited cells growth of MDA-MB-231 with an IC₅₀value about 5.0 μM.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231
Concentration:	0, 1, 2, 5 μM
Incubation Time:	4-6 days
Result:	Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.

体内研究
(In Vivo)

Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model^[1].

Animal Model:	Balb/c mice bearing 4T1 breast tumors^[1]
Dosage:	1.5 mg/kg
Administration:	Injection; 3 weeks
Result:	Reduced the tumor size and weight significantly without body weight changing.

Clinical Trial

分子量

307.43

Formula

C₂₁H₂₅NO

CAS 号

86-13-5

中文名称

苯甲托品

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.