CAS NO: | 82900-57-0 |
包装 | 价格(元) |
10mg | 询价 |
50mg | 询价 |
Cas No. | 82900-57-0 |
化学名 | 1-(3-(benzo[d][1,3]dioxol-5-yloxy)propyl)-4-phenylpiperazine maleate |
Canonical SMILES | O=C(O)/C([H])=C([H])\C(O)=O.C1(N2CCN(CC2)CCCOC3=CC4=C(OCO4)C=C3)=CC=CC=C1 |
分子式 | C20H24N2O3.C4H4O4 |
分子量 | 456.48 |
溶解度 | <45.65mg/ml in DMSO |
储存条件 | Store at RT |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | BP-554 maleate is a selective agonist of 5-HT1A receptor [1]. The 5-HT1A receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and mediates inhibitory neurotransmission. BP-554 maleate is a selective 5-HT1A receptor agonist. BP-554 showed higher affinity for 5-HT1A receptor than for 5-HT1-non-A, 5-HT2, α2-adrenergic, dopamine D2 and benzodiazepine receptors. In rat hippocampal membranes, BP-554 inhibited the activity of adenylate cyclase stimulated by forskolin [1]. In mice, BP-554 inhibited the accumulation of 5-hydroxytryptophan after decarboxylase inhibition and reduced the concentration of 5-hydroxy-indoleacetic acid in the brain. Also, BP-554 increased the levels of serum corticosterone and induced hypothermia [1]. The 5-HT1(A) receptor, 5-HT, brain-derived neurotrophic factor (BDNF) receptor trkB and BDNF formed an auto/paracrine loop to regulate the serotonergic phenotype. In rats, BP-554 dose-dependently increased amounts of neurons expressing serotonergic markers [2]. In monkeys, injection of BP554 into the primary visual cortex decreased multiunit activity (MUA) without influenced blood oxygen-level-dependent (BOLD) and local field potential (LFP) activity [3]. References: |
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