Acetylastragaloside I

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

84687-47-8

Acetylastragaloside I 是一种糖苷，可以从长小苞蔓黄芪的根中分离出。Acetylastragaloside I 是第一个具有显著的锥虫杀灭活性的环阿坦型三萜，对布氏罗得西亚锥虫和美洲锥虫的IC₅₀值分别为 9.5 和 5.0 μg/mL。Acetylastragaloside I 可用于锥虫感染的研究。

生物活性

Acetylastragaloside I is a glycoside that can be isolated from the roots ofAstragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity withIC₅₀values of 9.5 and 5.0 μg/mL forT. brucei rhodesienseandT. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosomeinfection^[1].

IC₅₀& Target

IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)^[1]

体外研究
(In Vitro)

Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity toT. brucei rhodesiense,T. cruzi,L. donovaniandP. falciparumwith IC₅₀values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively^[1].
Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	Rat skeletal myoblasts (L6) cell line
Concentration:	0.123-90 μg/mL
Incubation Time:	72 hours
Result:	Showed cytotoxicity to L6 cells with an IC₅₀value of 24.2 μg/mL.

分子量

911.08

Formula

C₄₇H₇₄O₁₇

CAS 号

84687-47-8

结构分类

Others

来源

Plants
Leguminosae
Astragalus membranaceusvar. mongholicus (Bunge)P.K.Hsiao

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.