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Pectin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:9000-69-5

Pectin 是一种杂多糖,可从高等植物的细胞壁获得。Pectin 能够制成纳米颗粒,作为药物的运载载体。Pectin 也是一种吸附剂,一种广谱抗菌剂,可以结合肠道粘膜中的细菌毒素和其他刺激物,缓解受刺激的黏膜。
生物活性

Pectin is a heteropolysaccharide, derived from the cell wall of higherplants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulatingPaclitaxel(HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1].
Pectin (3, 6 mg/mL; 48 h) inhibitsStaphylococcus aureusATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2].
Pectin inhibits Gram-negativeHelicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2].
Pectin displays lower antibacterial activity againstE. coliwith MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2].
Pectin exhibits the antibacterial activity via its undissociated acid form[2].

体内研究
(In Vivo)

Pectin serves as the nanoparticles encapsulatingPaclitaxel(HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1].

Clinical Trial
CAS 号

9000-69-5

结构分类
  • Saccharides
  • Polysaccharides
  • Others
来源
  • Plants
  • Rosaceae
  • Malus pumilaMill.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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