Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of theκ-opioid receptor. Dynorphin A (1-10) also blocksNMDA-activated current with anIC₅₀of 42.0 μM.

Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor^[1]. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC₅₀is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I_NMDAto a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors^[2].

1234.45

C₅₇H₉₁N₁₉O₁₂

79994-24-4

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro

YGGFLRRIRP

Room temperature in continental US; may vary elsewhere.

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