Cathepsin L/S-IN-1

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Cathepsin L/S-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Cathepsin L/S-IN-1 是组织蛋白酶L和S的双重抑制剂，IC₅₀分别为 4.10 μM 和 1.79 μM。Cathepsin L/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。

生物活性

CathepsinL/S-IN-1 is a dual inhibitor ofCathepsinLandSwithIC₅₀s of 4.10 μM and 1.79 μM, respectively.CathepsinL/S-IN-1 shows a significant antimetastatic and invasive effects on pancreaticcancerBxPC-3 and PANC-1 cells^[1].

IC₅₀& Target^[1]

cathepsin L

4.10 μM (IC₅₀)

cathepsin S

1.79 μM (IC₅₀)

体外研究
(In Vitro)

Cathepsin L/S-IN-1 (化合物 B1a) (0-25 μM; 48 h) 显示对胰腺癌 BxPC-3 和 PANC-1 细胞无细胞毒性^[1]。
Cathepsin L/S-IN-1 (0-25 μM; 48 h) 抑制组织蛋白酶 L 和 S 活性，而不降低它们的 mRNA 水平^[1]。
Cathepsin L/S-IN-1 (0-25 μM; 48 h) 抑制胰腺癌 BxPC-3 和 PANC-1 细胞的迁移和侵袭^[1]。

Cell Viability Assay^[1]

Cell Line:	BxPC-3 and PANC-1 cells
Concentration:	0, 6.25, 12.5, and 25 μM
Incubation Time:	48 hours
Result:	Failed to suppress the viability of pancreatic cancer cells.

分子量

613.57

Formula

C₂₉H₃₃BrN₄O₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.