Succinyl phosphonate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

26647-82-5

Succinyl phosphonate 是 α-酮戊二酸脱氢酶 (KGDHC) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的ROS产生。

生物活性

Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle,bacterial, brain, and cultured human fibroblasts^[1]^[4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability ofcancercells in a cell-specific metabolism-dependent manner^[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-inducedROSproduction in glutamate-stimulated hippocampal neurons in situ^[3].

IC₅₀& Target

α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase^[1]^[4]; ROSproduction^[3]

分子量

182.07

性状

Oil

Formula

C₄H₇O₆P

CAS 号

26647-82-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month