PROTAC IRAK4 degrader-2

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CAS NO:

2374122-27-5

PROTAC IRAK4 degrader-2 (Compound 9) 是一种PROTAC IRAK4降解剂，在外周血单个核细胞 (PBMC) 中，降解 IRAK4，DC₅₀为 151 nM。PROTAC IRAK4 Degrader-2 在 PBMC 细胞中诱导 IRAK4 蛋白水平降低，DC₅₀为 36 nM。PROTAC IRAK4 degrader-2 还抑制 PBMC 中多种细胞因子释放。

生物活性

PROTACIRAK4 degrader-2 (Compound 9) is aPROTAC-basedIRAK4degrader that affords potentIRAK4degradation with aDC₅₀in peripheral blood mononuclear cells (PBMCs) cells of 151 nM.PROTACIRAK4 degrader-2 induce a reduction ofIRAK4protein levels with aDC₅₀of 36 nM in PBMC cells.PROTACIRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs^[1].

体外研究
(In Vitro)

PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 22 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner^[1].
PROTAC IRAK4 degrader-2 (compound 9) (0.01~10 μM; 24 hours; PBMCs) induces a reduction of IRAK4 protein levels^[1].

Western Blot Analysis^[1]

Cell Line:	PBMCs
Concentration:	0.01, 0.03, 0.1, 0.3, 1, 3 and 10 μM
Incubation Time:	22 and 24 hours
Result:	Induced a reduction of IRAK4 protein levels with a DC₅₀value of 36 nM and IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.

分子量

1086.28

Formula

C₅₇H₆₈FN₁₁O₈S

CAS 号

2374122-27-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.