Eleutherobin

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Eleutherobin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

174545-76-7

Eleutherobin 是一种有效的 β 微管蛋白 (β-microtubule)，IC₅₀为 2 μM。Eleutherobin 可从海洋软珊瑚中提取。Eleutherobin 对癌细胞的细胞毒活性具有与紫杉醇 (Paclitaxel; HY-B0015)) 相似的效力。具有抗癌活性。

生物活性

Eleutherobin is a potentβ-microtubuleinhibitor with anIC₅₀value of 2 μM. Eleutherobin can be isolated from a marine soft coral. Eleutherobin has cytotoxic activity againstcancercells with similar potency to that ofPaclitaxel(HY-B0015). Anticancer activity^[1]^[2].

IC₅₀& Target

IC₅₀: 2 μM (β-microtubule)^[1]

体外研究
(In Vitro)

Eleutherobin (0-600 nM; 72 h) exhibits cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	HCT116, HCT116 (VM46), A2780 and A2780/Tax22
Concentration:	0-600 nM
Incubation Time:	72 h
Result:	Exhibited cytotoxic activity against HCT116, HCT116 (VM46), A2780 and A2780/Tax22 with IC₅₀s of 10.7 nM, 554 nM, 13.7 nM and 59 nM.

分子量

656.76

Formula

C₃₅H₄₈N₂O₁₀

CAS 号

174545-76-7

结构分类

Alkaloids
Other Alkaloids

来源

coral

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.