P-gp inhibitor 5

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P-gp inhibitor 5

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CAS NO:

2451298-06-7

P-gp inhibitor 5 是一种有效的P 糖蛋白 (P-gp)抑制剂。P-gp inhibitor 5 对某些癌细胞有抗增殖活性。P-gp inhibitor 5 可通过恢复细胞对长春新碱 (Vincristine; HY-N0488A) 和紫杉醇 (Paclitaxel; HY-B0015) 的敏感性，有效逆转 ABCB1/Flp-In^TM-293 和 KBvin 的多药耐药 (MDR) 表型。

生物活性	P-gp inhibitor 5 is a potentP-glycoprotein(P-gp)inhibitor. P-gp inhibitor 5 has antiproliferative activity against certaincancercell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-In^TM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015)^[1].
IC₅₀& Target	P-gp^[1]
体外研究 (In Vitro)	P-gp inhibitor 5 (compound 10) has cytotoxic against ABCB1/Flp-In^TM-293 and KBvin cells with IC₅₀s of 29.7 and 12.6 μM, respectively^[1]. P-gp inhibitor 5 (2.5 and 5 μM) lows the IC₅₀s of KBvin cells for Vincristine to 7.59~36.82 nM, for Paclitaxel to 21.0~79.5 nM, for Doxorubicin to 85.7~111 nM; lows the IC₅₀s of HeLaS3 cells for Vincristine to 2.24~3.91 nM, for Paclitaxel to 8.81~9.58 nM, for Doxorubicin to 102~1260 nM^[1].
分子量	517.98
Formula	C₂₈H₂₀ClNO₅S
CAS 号	2451298-06-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.