5-Geranoxy-7-methoxycoumarin

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CAS NO:

7380-39-4

5-Geranoxy-7-methoxycoumarin 是一种具有抗癌、抗真菌和抗菌活性的香豆素。5-Geranoxy-7-methoxycoumarin 诱导细胞凋亡(apoptosis)。

生物活性

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cellapoptosis^[1]^[2].

体外研究
(In Vitro)

5-Geranoxy-7-methoxycoumarin (12.5-200 μM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells^[1].
5-Geranoxy-7-methoxycoumarin (50 μM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells^[1].
5-Geranoxy-7-methoxycoumarin (50 μM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation^[1].

Cell Proliferation Assay^[1]

Cell Line:	SW480
Concentration:	0-20 μM
Incubation Time:	24, 48 and 72 hours
Result:	Inhibited cell growth by 67% at 72 hours.

Apoptosis Analysis^[1]

Cell Line:	SW480 cells
Concentration:	50 μM
Incubation Time:	48 hours
Result:	Induced cell apoptosis.

Cell Cycle Analysis^[1]

Cell Line:	SW480 cells
Concentration:	50 μM
Incubation Time:	48 hours
Result:	Inhibited cell cycle progressionin vitro.

分子量

328.40

Formula

C₂₀H₂₄O₄

CAS 号

7380-39-4

结构分类

Phenylpropanoids
Coumarins

来源

Plants
Rutaceae
Citrus limon(L.) Burm. F.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.