Enmein

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Enmein

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

3776-39-4

Enmein 从I. serra中分离，具有免疫抑制作用。

生物活性

Enmein is isolated fromI. serrawith immunosuppressive effect^[1].

体外研究
(In Vitro)

Enmein shows significant inhibitory effect toward K562 with an IC₅₀value ranging from 3.2 μg/ml to 8.2 μg/ml^[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml^[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%^[1].

Cell Viability Assay^[1]

Cell Line:	Splenic lymphocyte cells
Concentration:	3.13, 6.25, 12.5, 25 μg/ml
Incubation Time:	48 hours
Result:	Exhibited an IC⁵⁰value of 17 μg/ml in splenic lymphocytes.

Cell Cycle Analysis^[1]

Cell Line:	Splenic lymphocyte cells
Concentration:	5.5 μg/ml, 11 μg/ml, 22 μg/ml
Incubation Time:	48 hours
Result:	Caused S stage cells and G2/M stage cells decreased.

体内研究
(In Vivo)

Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression^[1].

Animal Model:	Balb/c mice^[1]
Dosage:	6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
Administration:	Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
Result:	Had inhibitory effect on IL-2 release in blood.

分子量

362.42

Formula

C₂₀H₂₆O₆

CAS 号

3776-39-4

结构分类

Others

来源

Plants
Labiatae
Rabdosia serra(Maxim.) Hara

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.