Kushenol K

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Kushenol K

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CAS NO:

101236-49-1

苦参醇K

Kushenol K，一种从Sophora flavescens中提取的黄酮类抗氧化剂。Kushenol K 是CYP3A4的抑制剂，K_i值为 1.35 μM。Kushenol K 对HSV-2具有较弱的抗病毒活性 (EC₅₀为 147 μM)。Kushenol K 还抑制SGLT1和SGLT2的活性。

生物活性

Kushenol K, a flavonoid antioxidant isolated from the roots ofSophora flavescens. Kushenol K is acytochrome P-450 3A4 (CYP3A4)inhibitor with aK_ivalue of 1.35 μM^[1]. Kushenol K shows weak antiviral activity againstHSV-2(EC₅₀of 147 μM)^[2]. Kushenol K also inhibits the activity ofSGLT1andSGLT2^[3].

IC₅₀& Target^[1]^[2]^[3]

CYP3A4

1.35 μM (Ki)

CYP3

SGLT1

SGLT2

HSV-2

147 μM (EC₅₀)

体外研究
(In Vitro)

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC₅₀values of 1.62 μM^[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%^[3].

分子量

472.53

Formula

C₂₆H₃₂O₈

CAS 号

101236-49-1

中文名称

苦参醇K；苦参醇 K

结构分类

Flavonoids
Flavanonols

Phenols
Polyphenols

来源

Plants
Leguminosae
Sophora flavescens

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.