1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)

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CAS NO:

376362-03-7

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) 是从Broussonetia kazinoki中分离出来的，在体外对蛋白酪氨酸磷酸酶 1B (PTP1B) 具有抑制作用，IC₅₀为 13.00 μM。PTP1B 是胰岛素作用的负调节因子，是胰岛素抵抗和非胰岛素依赖型糖尿病发病机制中的重要介质。PTP1B 被认为是 2 型糖尿病的重要靶标。

生物活性	1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated fromBroussonetia kazinoki, shows in vitro inhibition of protein tyrosinephosphatase1B (PTP1B) with an IC₅₀of 13.00 μM. PTP1B is a negative regulator ofinsulinaction and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes^[1].
分子量	326.43
Formula	C₂₁H₂₆O₃
CAS 号	376362-03-7
结构分类	Phenols Polyphenols
来源	Plants Moraceae Broussonetia kazinokiSieb. et Zucc.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.