XAP044 是一种有效的、选择性的mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 (mGlu7) 是哺乳动物 CNS 中神经传递的重要突触前调节剂。XAP044 在啮齿动物行为范式中表现出良好的大脑暴露和广谱抗应激、抗抑郁和抗焦虑药功效。
| 生物活性 | XAP044 is a potent and selective antagonist ofmGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
