Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect^[1][2].

Substance P(6-11) 在大鼠膀胱中刺激 [³H]-肌醇一磷酸 ([³H]-IP1) 的形成，EC₅₀值为 4 nM。

Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放^[2]。

740.91

C₃₆H₅₂N₈O₇S

51165-07-2

QFFGLM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.