Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius^[1].

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions^[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord^[2].

900.04

C₄₁H₆₅N₁₃O₁₀

68060-49-1

Arg-Pro-Lys-Pro-Gln-Gln-Phe

RPKPQQF

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