(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P

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CAS NO:

115760-58-2

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P 是一种选择性的NK₁receptor拮抗剂。

生物活性

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selectiveNK₁receptorantagonist^[1].

IC₅₀& Target^[1]

NK1

分子量

1427.72

Formula

C₆₇H₁₀₂N₂₀O₁₃S

CAS 号

115760-58-2

Sequence Shortening

{D-Arg}-{D-Pro}-KPQQ-{D-Phe}-F-{D-His}-LM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.