Substance P(1-4)

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Substance P(1-4)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

57468-16-3

Substance P(1-4) 是一种有效的神经激肽受体(NK-R)拮抗剂。Substance P(1-4) 对正常造血有调节作用，抑制内源性红细胞集落 (EEC) 的形成。

生物活性

Substance P(1-4) is a potentneurokinin receptors (NK-R)antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation^[1].

体外研究
(In Vitro)

Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures^[1].
Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %^[1].

Cell Viability Assay^[1]

Cell Line:	PV CD36+/GpA- cells
Concentration:	0.1 nM-1 μM
Incubation Time:	2 days
Result:	Inhibited proliferation of PV CD36+/GpA- cells of 30 %.

Apoptosis Analysis^[1]

Cell Line:	PV CD36+/GpA- cells
Concentration:	10 nM
Incubation Time:	2 days
Result:	Increased the percentage of cell death of 27.3%.

分子量

496.60

Formula

C₂₂H₄₀N₈O₅

CAS 号

57468-16-3

Sequence Shortening

RPKP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.