Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1(PAR-1)agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds toPAR1tethered ligand and which can selectively mimic theactions ofthrombinvia this receptor^[1][2].

PAR-1^[1]

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Go 6976^[2].

762.90

C₃₅H₅₈N₁₀O₉

141136-85-8

Thr-Phe-Leu-Leu-Arg-Asn

TFLLRN

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.